Cancer many of clinical test of remedy in dead end

　The cancer where the promising result is obtained (the cancer) among IIth phase clinical tests of remedy, as for advancing to IIIth phase test just being little, was ascertained by the research of Canada and University of Toronto Ian Tannock doctors, the American cancer remedy academic society annual meeting which in June is held in Chicago (ASCO 2007) with was reported.

　The medicine which passes animal experiment reaches in the clinical place until, Ith phase, IIth phase, IIIth phase (phase there are 3 stages of I, II and III) test. As for Ith phase test, with the small-numbered subject safety of remedy and those which see the safe dosage quantity. As for IIth phase test, usually targeting 100 people or less, those which are seen the remedy in the cancer of specification which effective. When the satisfactory result is produced with IIth phase test, it advances to IIIth phase test. The large random (the random) it allots IIIth phase test, being something which compares the effect of standard cure with the new medicine, it requires huge fund. The american food medical supply bureau (FDA), the satisfactory result at IIIth phase is necessary in approval.

　In the latest research, the result of inspecting the IIth phase test 200 case where the promising result is recognized the breast and the lung, the digestive organs, the 泌 urine genital organ, concerning the cancer of gynecology, as for advancing to IIIth phase test only 13% clarification. As for many, you cannot obtain fund, it was not executed in the reason such that number of the necessary patients does not get together.

　Also it became clear for the case where however, this kind of restriction is recognized at planned point in time of IIth phase test to be many. As for Tannock, unless it advances first, while knowing, as for executing, you say that is, because there is a purpose, success of the researcher. Promotion of the cancer medical specialist depends on the announcement of dissertation, as for IIth phase test in order to do relatively at the number of dwarfs, the young researcher to the possibility being accustomed the “head researcher” is high in comparison with IIIth phase test. But, when it is not the case that the researcher has been conscious of that, the system so it points, Tannock has expressed.

　According to a certain researcher, among the United States execution of IIth phase test is much many in comparison with Europe. Between the doctors where the United States is young in addition to being the pressure which “Publish or Perish (writes dissertation, or in order to save the large amount cost which the medicine manufacture company focuses on IIIth phase test it disappears or)” with it says, on the basis of the result of small-scale IIth phase test, there are also times when already use outside adaptation of the FDA approval being completed medicine is encouraged. In addition, also the point which is difficult to gather the interest whose IIth phase test is wide simply is pointed out.

　Richard Schilsky doctor of ASCO and the circumstance “of Publish or Perish” has recognized IIth phase test excessive cause, a better remuneration system being necessary vis-a-vis the researcher who carries out important role in large-scale IIIth phase test, the general person the result of IIth phase test points out in order to catch prudently.

As for criminal of chronic fatigue syndrome

The feeling which thinks the son of the father, came to the point of advancing the cause elucidation of the disease which has been wrapped in puzzle. Chia Doctor John medical practitioner of American California state trance, in 1997 chronic fatigue syndrome (CFS) with CFS and (* with general term of the virus which multiplies with the alimentary canal, over 60 type existence) with showed relation in collaborative research Andrew Chia of the son who was diagnosed September 13th announced the knowledge to medical magazine “Journal of Clinical Pathology” online edition.

　In the United States, or more of the presumption 1,000,000 person has contracted a disease in CFS, it is questioned. Especially, in the many disease, the fatigue of cause obscurity, sleep obstacle, obstacle of memory power and concentration, 疼 and so on, you can see various weakening characteristic conditions painfully in the woman of the 40~60 year, the multiple sclerosis (MS) with there are also times when the same obstacle it does to come. It could recognize the existence of CFS for the first time on the eighties latter half, but at the beginning the dependance (the grommet [pi] [yo] [u]) also characteristic has been doubted. It is said other than [enterouirusu] that several viruses have participated in CFS, but it was difficult to find the basis which supports the participation of the virus.

　Chia first, picking the blood inspection body of approximately 3,000 from the patient, tried to find the virus gene. The time of 5~6 year was spent, although the fact that [enterouirusu] exists in 35% of the inspection bodies was pinpointed, this is the result of picking the plural inspection bodies from 1 patients, it makes 1 inspection bodies, when concerning 1 people under 5% it was restricted to the result which is said. Because of this Chia was not the blood, while organizing direction it converted to searching the virus.

　In past research, the brain of the CFS patient who commits suicide, the muscle, was discovered from the heart, but the brain of the patient who exists and biopsy of the heart in fact the impossibility. Chia paid attention to the stomach which is the place of multiplication of [enterouirusu] then. With the contrast group it was 20% long term digestive organs condition (it is seen often in the CFS patient) targeting CFS patient 165 it appeals, vis-a-vis [enterouirusu] being positive among 82% the inspection bodies of stomach biopsy and the result and the CFS patient who carry out endoscope inspection. As for first infection several years ago (before the longest 20 years) the patient who is was many.

　That everyone while paying attention in only the blood, Chia paying attention to the alimentary canal was connected to the discovery of the virus, a certain specialist points out. [enterouirusu] is no more than a portion of the cause of CFS, but the thought of assuming that CFS is the infection characteristic disease, when it is something which makes the world agree upon Chia calls. Andrew Chia of the son now has recovered, but Chia has expressed “if the son was not, there was no this research”, that.