Showing posts with label Alzheimer. Show all posts
Showing posts with label Alzheimer. Show all posts

Wednesday, August 29, 2007

Decrease of olfactory sense in estimate factor of Alzheimer's disease

Decrease of olfactory sense in estimate factor of Alzheimer's disease

The possibility decrease of the olfactory sense being early sign of acknowledgment obstacle was shown, was published to the American medical magazine “Archives of General Psychiatry” July edition. The american rush Rush Alzheimer's disease center which leads research (Chicago) Robert S of nervous psychology professor. according to Wilson, what already you can see the decrease of the olfactory sense in the person who has minor acknowledgment obstacle is reported to the past, but as for designating the person who completely does not have acknowledgment obstacle when starting the research as the object you say that this research is unprecedented.

 In the latest research, targeting senior citizen 589 of average age approximately 80 years old, you make the smell of 12 types smell, carrying out the olfactory sense inspection which respectively makes the same smell choose from four choices. After that, inspection of nervous function and acknowledgment function year 1 time and 5 years it went. During research period 117 people early sign of the Alzheimer's disease emergence the minor acknowledgment obstacle which is doubted. As for the person where record of olfactory sense inspection is under average, emergence ratio of minor acknowledgment obstacle 50% high thing it was understood in comparison with the person who is above average. As for the result, the Alzheimer's disease starts from obstacle of the specific region of the brain, when it is something which agrees to the thought that spreading and keeping damaging the thought territory Wilson has expressed.

 American Alzheimer's disease association (AA) Gandy Doctor SAM of medical scientific Advisory Committee although this theory approximately is supported, you insist, that olfactory sense inspection becomes index of acknowledgment obstacle, points out that the appraisal with double blind method with the second and third group is needed.

 The developer of the olfactory sense inspection which is used in the latest research, Richard L of American Pennsylvania university medical center. according to Doty, you call this inspection that it has already been utilized at the clinical place. The parkinson's disease and the person who has the patient of the Alzheimer's disease in the blood related person targeting in the result and after carry out this inspection the disease in the person who emerges what you can see the decrease of the olfactory sense is shown, says that the nervous course medicine which utilizes this inspection in diagnosis of discrimination it is.

 It can execute this inspection in about 5 minutes, but now when according to Wilson, there is no effective cure which stops the advance of the Alzheimer's disease, you say that it is not the case that, everyone should receive this inspection directly. But, the medicine which designates the amyloid accumulation of the brain as the target being promising is shown and the remedy which if stops the advance of the disease becomes possible, you say that there is a meaning even in early detection. However, it is not olfactory sense inspection independently diagnosis even with in that case, we have assumed that it means to be used as one among various methods.

The cause protein of the Alzheimer's disease (the protein) participates in also glaucoma

The cause protein of the Alzheimer's disease (the protein) participates in also glaucoma


 Old person unevenness (the plaque) the amyloid which is formed - ## (beta) the protein (the protein), the possibility of becoming cause of retina cell death in the glaucoma it was shown in the brain of the Alzheimer's disease patient, “Proceedings of the National Academy of Science (PNAS)” of the American scientific academy issue August 7th was published to online edition (printing edition August 10-16th in the number publication).

 In the latest research, the English London university (UCL) M. as for Francesta Cordeiro doctors, vis-a-vis the rut/rat which in order to emerge, operated glaucoma the amyloid - when the medicine which obstructs the formation route ## is used, the damage of the eye lightened, life of the retina cell extended. When obstruction of formation route was tried with method of several types, when the effect is highest in 1 types among those, jointly uses the method of all type, you say that furthermore you could see the big effect.

 As for this knowledge, there is also a possibility of becoming the key which solves the doubt which has surfaced recently between the ophthalmologists concerning glaucoma remedy. To several years ago, glaucoma is stated when it is something where retina cell death happens with the abnormal rise of eye pressure, the remedy which presently lowers eye pressure mainly is done, but to tell the truth as for eye pressure normally close thing has known above the half of the glaucoma patient. We have assumed that the American ophthalmology academic society (AAO) presently, eye pressure rise it deletes the description which we assume, that it is cause of glaucoma, simply main dangerous factor (the risk factor) is.

 As for Corderio, the amyloid - you observe to ## by the fact that you could see the retina cell death which is similar to glaucoma in the Alzheimer's disease patient. Besides the fact that the amyloid - it could recognize the accumulation ## in the retina cell which becomes extinct, when the amyloid - it adds ## in the retina cell which was cultured cell death being induced it was recognized. When also the possibility where it can remedy the Alzheimer's disease the eye from this research, as the entrance of the body using it is Corderio has expressed.

 The american duke university (North Carolina) Stuart J. McKinnon doctor, method of thinking where there is a root of this research although it makes proper, there is no animal model where eye pressure glaucoma is superior low, in the latest research, pointing out the point which uses the rut/rat model which emerges glaucoma to a high eye pressure. Appraisal has expressed that it should make prudent. In addition, also cause of cell death being unclear, you do not know whether being the difference of the gene, whether it is difference of the sensitivity for eye pressure. But, it is certain, for the road to the new cure where in any case the amyloid - it designates ## as the target to be opened sooner or later when also the possibility of the vaccine actualization which prevents plaque formation it is as for the specialists you express.