General anesthetic medicine hypertension of man in cause
Aceto amino foehn and eve professional foehn which are the most general anesthetic medicine, as for the middle to elderly-aged man who uses aspirin periodically, the report that, was published to the American medical magazine “Archives of Internal Medicine” February 26th number emergence risk of the hypertension is high.
The american [burigamu] and [uimenzu] hospital which executes research (BWH, Boston) according to Gary Curhan doctor, aspirin and the non steroid characteristic anti- inflammation medicine (NSAID) the bleeding risk by is informed from the time before. When adaptation is not clear, it should restrict being, when there is a chronic condition which needs the anesthetic medicine, when it is necessary to examine the doctor and substitution remedy the same person you express this kind of medicine. Another specialist, these anesthetic medicines really point out that they are not extent safe ones which we think.
Past relation between the anesthetic medicine and the hypertension is shown in two large-scale research, but it was something where each of them deals with the woman. In another research, using the anesthetic medicine which begins NSAID frequently, as for hypertension risk of the healthy man unless it increases, the result had been produced, but in the latest research the same result as the woman was shown.
The research group the man medical work person 10,000 6,031 people who do not have the case history of the hypertension targeting (the even 64.6 years old) executing research. The participant offering information each aceto amino foehn, NSAID (eve professional foehn and [napurokisen] etc) and concerning the usage condition of aspirin. Pursuit of 4 years the result of doing, 1,968 people emerged the hypertension. Aceto amino foehn, NSAID, aspirin week 6~7 day as for the man who is used, hypertension risk 34%, 38% and 26% was high respectively in comparison with the man who is not used completely. In addition, these medicines as for the person who week 15 lock or more is taken, hypertension risk 48% was high in comparison with the person who is not used completely.
Each anesthetic medicine, relaxes the blood vessel and is thought that there is the action which obstructs the chemical substance which decreases the blood pressure, but furthermore it is necessary to repeat research. When it is to pinpoint whether or not after the long period of time using it takes medication discontinues, when, the blood pressure is falls the anesthetic medicine, Curhan you express the following step. In addition, from the fact that it is not the case that the person who uses the anesthetic medicine always becomes the hypertension, it is the group whose especially risk is high that also the fact that it specifies is topic.
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Showing posts with label medicine. Show all posts
Showing posts with label medicine. Show all posts
Friday, September 7, 2007
Saturday, September 1, 2007
In ACE obstruction medicine of step-down medicine lung cancer (cancer) reduction effect
In ACE obstruction medicine of step-down medicine lung cancer (cancer) reduction effect
The angiotensin conversion enzyme which is used for the remedy of the hypertension widely (ACE) in the obstruction medicine, the lung cancer (the cancer) having the effect which makes reduce was shown in research of the mouse. Also research with the person is planned soon and the curative effect whose if harmful characteristic is little becomes profitable and others [ru] thing, it means to bring new desire in the lung cancer remedy whose survival ratio is low.
The ACE obstruction medicine shows the step-down effect by the fact that formation of the angiotensin Ⅱ where becomes also cause of boosting is obstructed, but the angiotensin which possesses blood vessel expansion action simultaneously - (1-7) with the endogenous peptide which is called (the hormone) it has the function which it increases.
According to the research which is reported to the medical magazine “Cancer Research” March 15th number, the research team of the American [ueikuhuoresuto] Wake Forest university medical department pays attention to emergence ratio of the lung cancer being low in the hypertension patient who uses the ACE obstruction medicine. Furthermore the result which is researched in detail, the angiotensin - (1-7) [shikurookishigenaze] which is the enzyme which urges the growth of the cell (cox-2) the fact that it is the action which is made to decrease was pinpointed.
The same university Patricia E. Gallagher transplanted the cancer cell which was picked from the patient of 58 years old to the mouse of 2~4 age in weeks, grew the tumor 32 days. Half the angiotensin of the mouse - (1-7) in order 28 days, to become density in the same blood as the person who receives ACE obstruction medicine remedy, it injected, prescribed the physiological brine to the remaining mouse. The result of dissection after the ending, the angiotensin - (1-7) with the dosage group cox-2 density decreases significantly, as for the tumor of the physiological brine dosage group says the tumor 30% vis-a-vis having reduced, that it grew in 2.5 times that before the dealing with. The angiotensin - (1-7) the poisonous side effect was not seen in the mouse which is prescribed, weight and heart rate, change was not seen even in the blood pressure.
Concerning dosage and remedy period furthermore it is necessary to repeat research, but that if you can obtain the satisfactory result in research with the person who is started soon, it probably reaches the point where this kind of medicine carries out important role in lung cancer remedy, Gallagher has expressed. With the combined use with the remedy of other things, be able to expect also the possibility where it can decrease the chemotherapy which has the side effect, even if, it is thought even with the small effect that it becomes big help, for the patient. Furthermore another specialist, utilizing the substance of organism origin, has expressed that it is something which shows the possibility of creating the new remedy.
The american cancer association (ACS) according to, the lung cancer both the man and woman rather than at 1st rank of cause of the death with the cancer, the colon (the colon) adjusting the cancer, the breast cancer and the prostate cancer many Americans has died with the lung cancer. In 10 people 6 people from diagnosis to die within 1 years, as for 5 year survival ratio only 14%. The number of death in the United States people is presumed the annual 170,000 person.
The angiotensin conversion enzyme which is used for the remedy of the hypertension widely (ACE) in the obstruction medicine, the lung cancer (the cancer) having the effect which makes reduce was shown in research of the mouse. Also research with the person is planned soon and the curative effect whose if harmful characteristic is little becomes profitable and others [ru] thing, it means to bring new desire in the lung cancer remedy whose survival ratio is low.
The ACE obstruction medicine shows the step-down effect by the fact that formation of the angiotensin Ⅱ where becomes also cause of boosting is obstructed, but the angiotensin which possesses blood vessel expansion action simultaneously - (1-7) with the endogenous peptide which is called (the hormone) it has the function which it increases.
According to the research which is reported to the medical magazine “Cancer Research” March 15th number, the research team of the American [ueikuhuoresuto] Wake Forest university medical department pays attention to emergence ratio of the lung cancer being low in the hypertension patient who uses the ACE obstruction medicine. Furthermore the result which is researched in detail, the angiotensin - (1-7) [shikurookishigenaze] which is the enzyme which urges the growth of the cell (cox-2) the fact that it is the action which is made to decrease was pinpointed.
The same university Patricia E. Gallagher transplanted the cancer cell which was picked from the patient of 58 years old to the mouse of 2~4 age in weeks, grew the tumor 32 days. Half the angiotensin of the mouse - (1-7) in order 28 days, to become density in the same blood as the person who receives ACE obstruction medicine remedy, it injected, prescribed the physiological brine to the remaining mouse. The result of dissection after the ending, the angiotensin - (1-7) with the dosage group cox-2 density decreases significantly, as for the tumor of the physiological brine dosage group says the tumor 30% vis-a-vis having reduced, that it grew in 2.5 times that before the dealing with. The angiotensin - (1-7) the poisonous side effect was not seen in the mouse which is prescribed, weight and heart rate, change was not seen even in the blood pressure.
Concerning dosage and remedy period furthermore it is necessary to repeat research, but that if you can obtain the satisfactory result in research with the person who is started soon, it probably reaches the point where this kind of medicine carries out important role in lung cancer remedy, Gallagher has expressed. With the combined use with the remedy of other things, be able to expect also the possibility where it can decrease the chemotherapy which has the side effect, even if, it is thought even with the small effect that it becomes big help, for the patient. Furthermore another specialist, utilizing the substance of organism origin, has expressed that it is something which shows the possibility of creating the new remedy.
The american cancer association (ACS) according to, the lung cancer both the man and woman rather than at 1st rank of cause of the death with the cancer, the colon (the colon) adjusting the cancer, the breast cancer and the prostate cancer many Americans has died with the lung cancer. In 10 people 6 people from diagnosis to die within 1 years, as for 5 year survival ratio only 14%. The number of death in the United States people is presumed the annual 170,000 person.
Wednesday, August 29, 2007
With diabetes medicine heart failure risk in 2 times
With diabetes medicine heart failure risk in 2 times
Diabetes remedy Avandia ([abandeia] and general name: rosiglitazone [roshiguritazon], in the Japanese country not yet approval) or [akutosu] ([pioguritazon]) as for the patient who uses each of them, the report that, was published to the medical magazine “Diabetes Care” August edition the emergence risk of heart failure is 2 times in comparison with the patient who is not used. The same family ([chiazorijin] system) with the medicine which belongs, the diabetes patient who exceeds 3,000,000 person in the United States has used Avandia and [akutosu]. In current label indication, in order to avoid the combined use with the use and the insulin with the grave heart failure patient, it is warned, but according to the latest knowledge, you say that risk increase could recognize to also the patient who does not correspond to this.
The american food medical supply bureau which is announced to the preceding day of this report (FDA) in the research by the review team, when Avandia the risk which brings heart obstacle in comparison with [akutosu], is high substantially, the result was shown. According to the New York times paper, with the patient who has already used the insulin as for the side effect it is assumed to combined use with [akutosu] and the insulin vis-a-vis the risk due to especially Avandia being large, that it is not. This data is something which relates to the sale continuation of Avandia, whether or not the profit due to remedy exceeds risk when is important, one person of the team of FDA has expressed.
In research “of Diabetes Care” publication, the American [ueikuhuoresuto] Wake Forest university (North Carolina) Sonal Singh doctors of the medical department, collecting the data patient 70,000 8,000 or more either Avandia or [akutosu] is used. As a result, besides the fact that it could recognize redoubling the heart failure risk, what you can see risk increase as high dosage low with whichever of dosage was ascertained. Average period to heart failure emergence from start of use of medicine 24 weeks. 25% of emergence examples under 60 not to be restricted years old and, to just the senior citizen, both the man and woman being seen it was recognized. As for the research group, as for cause of risk increase that we have presumed, whether it is not something due to moisture storage you have expressed that it is necessary to amend the current guideline.
This year (2007) when the American Cleveland clinic (Ohio state) Steven E. Nissen, heart seizure risk 43% increases with the use of Avandia, we announce knowledge to May, argument is continued even now. According to the New York times, as for public information charge Mary Anne Rhyne of the production original [gurakuso] [sumisukurain] corporation of Avandia, as for opinion of the same company which we assume that the same medicine is safe, vis-a-vis the review of FDA, you have expressed that it does not change. With the data of the same company increase of the heart blood vessel death with Avandia is not recognized, you say that either difference of heart seizure emergence ratio is not recognized with the other medicine. Andy Zambanini doctor of the same company clinical development patsy says that presently FDA and negotiation are continued concerning the new alarm display regarding heart failure.
But as for Nissen, as for the patient who examines the use of Avandia the doctor it should consult well, just this news should stop the medicine which presently has been used for the reason, unless, opinion. The american diabetes association (ADA) Larry Deeb, if you use each medicine just, insists that it is safe. But as for the heart failure risk by both medicines in 50 1 people, if it is possible to ascertain the 1 people, to express that it is possible to remedy 49 people who remain safely because you can see the risk increase of heart failure and the heart seizure, saying, if it is not and uses the necessity to discontinue marketing both medicines appropriately it has expressed opinion that it is the useful medicine.
(Compilation gathering =FDA as for Advisory Committee July 31st at the commission which is held, as for possibility of the heart diseased risk increase of Avandia although it recognized, sale continuation of the same medicine was approved with majority of 22 to 1.)
Diabetes remedy Avandia ([abandeia] and general name: rosiglitazone [roshiguritazon], in the Japanese country not yet approval) or [akutosu] ([pioguritazon]) as for the patient who uses each of them, the report that, was published to the medical magazine “Diabetes Care” August edition the emergence risk of heart failure is 2 times in comparison with the patient who is not used. The same family ([chiazorijin] system) with the medicine which belongs, the diabetes patient who exceeds 3,000,000 person in the United States has used Avandia and [akutosu]. In current label indication, in order to avoid the combined use with the use and the insulin with the grave heart failure patient, it is warned, but according to the latest knowledge, you say that risk increase could recognize to also the patient who does not correspond to this.
The american food medical supply bureau which is announced to the preceding day of this report (FDA) in the research by the review team, when Avandia the risk which brings heart obstacle in comparison with [akutosu], is high substantially, the result was shown. According to the New York times paper, with the patient who has already used the insulin as for the side effect it is assumed to combined use with [akutosu] and the insulin vis-a-vis the risk due to especially Avandia being large, that it is not. This data is something which relates to the sale continuation of Avandia, whether or not the profit due to remedy exceeds risk when is important, one person of the team of FDA has expressed.
In research “of Diabetes Care” publication, the American [ueikuhuoresuto] Wake Forest university (North Carolina) Sonal Singh doctors of the medical department, collecting the data patient 70,000 8,000 or more either Avandia or [akutosu] is used. As a result, besides the fact that it could recognize redoubling the heart failure risk, what you can see risk increase as high dosage low with whichever of dosage was ascertained. Average period to heart failure emergence from start of use of medicine 24 weeks. 25% of emergence examples under 60 not to be restricted years old and, to just the senior citizen, both the man and woman being seen it was recognized. As for the research group, as for cause of risk increase that we have presumed, whether it is not something due to moisture storage you have expressed that it is necessary to amend the current guideline.
This year (2007) when the American Cleveland clinic (Ohio state) Steven E. Nissen, heart seizure risk 43% increases with the use of Avandia, we announce knowledge to May, argument is continued even now. According to the New York times, as for public information charge Mary Anne Rhyne of the production original [gurakuso] [sumisukurain] corporation of Avandia, as for opinion of the same company which we assume that the same medicine is safe, vis-a-vis the review of FDA, you have expressed that it does not change. With the data of the same company increase of the heart blood vessel death with Avandia is not recognized, you say that either difference of heart seizure emergence ratio is not recognized with the other medicine. Andy Zambanini doctor of the same company clinical development patsy says that presently FDA and negotiation are continued concerning the new alarm display regarding heart failure.
But as for Nissen, as for the patient who examines the use of Avandia the doctor it should consult well, just this news should stop the medicine which presently has been used for the reason, unless, opinion. The american diabetes association (ADA) Larry Deeb, if you use each medicine just, insists that it is safe. But as for the heart failure risk by both medicines in 50 1 people, if it is possible to ascertain the 1 people, to express that it is possible to remedy 49 people who remain safely because you can see the risk increase of heart failure and the heart seizure, saying, if it is not and uses the necessity to discontinue marketing both medicines appropriately it has expressed opinion that it is the useful medicine.
(Compilation gathering =FDA as for Advisory Committee July 31st at the commission which is held, as for possibility of the heart diseased risk increase of Avandia although it recognized, sale continuation of the same medicine was approved with majority of 22 to 1.)
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