In ACE obstruction medicine of step-down medicine lung cancer (cancer) reduction effect

In ACE obstruction medicine of step-down medicine lung cancer (cancer) reduction effect


　The angiotensin conversion enzyme which is used for the remedy of the hypertension widely (ACE) in the obstruction medicine, the lung cancer (the cancer) having the effect which makes reduce was shown in research of the mouse. Also research with the person is planned soon and the curative effect whose if harmful characteristic is little becomes profitable and others [ru] thing, it means to bring new desire in the lung cancer remedy whose survival ratio is low.

　The ACE obstruction medicine shows the step-down effect by the fact that formation of the angiotensin Ⅱ where becomes also cause of boosting is obstructed, but the angiotensin which possesses blood vessel expansion action simultaneously - (1-7) with the endogenous peptide which is called (the hormone) it has the function which it increases.

　According to the research which is reported to the medical magazine “Cancer Research” March 15th number, the research team of the American [ueikuhuoresuto] Wake Forest university medical department pays attention to emergence ratio of the lung cancer being low in the hypertension patient who uses the ACE obstruction medicine. Furthermore the result which is researched in detail, the angiotensin - (1-7) [shikurookishigenaze] which is the enzyme which urges the growth of the cell (cox-2) the fact that it is the action which is made to decrease was pinpointed.

　The same university Patricia E. Gallagher transplanted the cancer cell which was picked from the patient of 58 years old to the mouse of 2~4 age in weeks, grew the tumor 32 days. Half the angiotensin of the mouse - (1-7) in order 28 days, to become density in the same blood as the person who receives ACE obstruction medicine remedy, it injected, prescribed the physiological brine to the remaining mouse. The result of dissection after the ending, the angiotensin - (1-7) with the dosage group cox-2 density decreases significantly, as for the tumor of the physiological brine dosage group says the tumor 30% vis-a-vis having reduced, that it grew in 2.5 times that before the dealing with. The angiotensin - (1-7) the poisonous side effect was not seen in the mouse which is prescribed, weight and heart rate, change was not seen even in the blood pressure.

　Concerning dosage and remedy period furthermore it is necessary to repeat research, but that if you can obtain the satisfactory result in research with the person who is started soon, it probably reaches the point where this kind of medicine carries out important role in lung cancer remedy, Gallagher has expressed. With the combined use with the remedy of other things, be able to expect also the possibility where it can decrease the chemotherapy which has the side effect, even if, it is thought even with the small effect that it becomes big help, for the patient. Furthermore another specialist, utilizing the substance of organism origin, has expressed that it is something which shows the possibility of creating the new remedy.

　The american cancer association (ACS) according to, the lung cancer both the man and woman rather than at 1st rank of cause of the death with the cancer, the colon (the colon) adjusting the cancer, the breast cancer and the prostate cancer many Americans has died with the lung cancer. In 10 people 6 people from diagnosis to die within 1 years, as for 5 year survival ratio only 14%. The number of death in the United States people is presumed the annual 170,000 person.